Clindamycin/benzoyl peroxide gel has demonstrated clinical efficacy in the treatment of acne vulgaris through both antibacterial and anti-inflammatory means. Benzoyl peroxide may exert its antibacterial activity by the interaction of oxidized intermediates with elements of bacterial cells. Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunits causing inhibition of peptide-bond formation. Benzoyl peroxide decreases inflammatory damage by inhibiting the release of reactive oxygen species from polymorphonuclear leukocytes (PMNs) through the killing of PMNs. Clindamycin suppresses the complement-derived chemotaxis of polymorphonuclear leukocytes in vitro, thereby reducing the potential for inflammation. Several well designed clinical trials have demonstrated that twice-daily application of clindamycin 1%/benzoyl peroxide 5% gel for 10 to 16 weeks was more effective in reducing the number of inflammatory lesions than benzoyl peroxide 5%, clindamycin 1% or vehicle in patients with mild to moderately severe acne. Two studies also showed clindamycin/benzoyl peroxide to be more effective than benzoyl peroxide, clindamycin or vehicle in reducing total lesions, and one study showed clindamycin/benzoyl peroxide to be significantly more efficacious than clindamycin or vehicle in reducing the number of noninflammatory lesions. Moreover, in two trials, physician-rated mean global improvement scores, as well as patient-rated scores in one of those trials, were significantly greater in the clindamycin/benzoyl peroxide group than in the benzoyl peroxide, clindamycin or vehicle groups. In another study, clindamycin/benzoyl peroxide was as efficacious as benzoyl peroxide/erythromycin in the reduction of inflammatory and noninflammatory lesions and in raising mean global improvement scores, but was significantly more effective than benzoyl peroxide in the reduction of inflammatory lesions and in increasing both physician- and patient-assessed global improvement scores. Clindamycin/benzoyl peroxide gel applied twice daily was well tolerated in clinical trials in patients with acne, and has a tolerability profile similar to that of benzoyl peroxide alone. The most common adverse events were dry skin, peeling, erythema and rash; however, adverse event-caused treatment discontinuation rates for patients using clindamycin/benzoyl peroxide were low, ranging from 0 to 0.8%. Show
Conclusions: Clindamycin/benzoyl peroxide gel has demonstrated efficacy and good overall tolerability in several well designed clinical studies in the topical treatment of patients with mild to moderately severe acne vulgaris. Clindamycin/benzoyl peroxide was more effective than benzoyl peroxide, clindamycin or vehicle, and similar in efficacy to benzoyl peroxide/erythromycin in the reduction of inflammatory lesions and in raising physician- and patient-assessed mean global improvement scores. It may be useful in treating patients with acne caused by resistant strains of Propionibacterium acnes. Clindamycin/benzoyl peroxide gel is an effective topical agent in the treatment of patients with mild to moderately severe acne. It is a suitable alternative for patients who are currently using topical antibacterials either alone or in conjunction with other topical anti-acne agents or systemic antibacterials. So I debated about going to the derm for years. I had acne since I was 14 but always used OTC products. However, I finally decided to go when I was 23. The derm prescribed me with clindamycin phosphate gel in the morning and adapalene cream at night. The first few days using weren't bad, but after the first week, my face got so dry and extremely itchy. I also had a burning feeling everytime i touc... Most voted negative review1 People found this comment helpful Allergic reaction (rash/swelling of face & throat). Over the counter allergy medicine not helping. IMPORTANT INFORMATION ABOUT USER-GENERATED CONTENT ON WEBMDThe opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Male, 33. Persistent acne most my life. Tried 2 rounds Accutane. doxycycline, Retin A, Retin A Micro, various prescription topicals. Finally gave 2.5% BP a try...It dried out my skin for 3 weeks and I broke out worse, BUT THEN, my skin adjusted, finally, and 8 months later I've literally had maybe one small pimple a month. It is literally the only thing that has worked permanently for me. I've t... Most voted negative review9 People found this comment helpful no IMPORTANT INFORMATION ABOUT USER-GENERATED CONTENT ON WEBMDThe opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Does anti acne gel work?The anti acne face gel is fast-acting, versatile, and has a power-packed 4 in 1 action, that not only exfoliates, controls oil, reduces inflammation, and promotes rapid healing but also deeply penetrates pores to destroy acne-causing bacteria from the skin surface. What is the rating of benzoyl peroxide gel?Benzoyl peroxide topical has an average rating of 7.8 out of 10 from a total of 51 reviews on Drugs.com. 71% of reviewers reported a positive experience, while 13% reported a negative experience. What is benzoyl peroxide gel IP used for?BENZOYL PEROXIDE (BEN zoe ill per OX ide) treats acne or rosacea. It works by decreasing inflammation and killing or preventing the growth of bacteria on your skin. It belongs to a group of medications called antibiotics. What are the ingredients in benzac AC 5?BENZAC AC is available in three strengths: 2.5%, 5% or 10% of benzoyl peroxide. Gel base contains docusate sodium, disodium edentate, poloxamer 182, carbomer 940, propylene glycol, acrylates copolymer, glycerol, silicon dioxide, sodium hydroxide and purified water. |
