Show
Don't miss the signs of potentially life-threatening digoxin toxicitySigns of digoxin toxicity include:
Cardiac Dysrhythmias3,4
Laboratory Parameters2,3
Evidence of End-Organ Dysfunction2
Any ONE may indicate the need for IMMEDIATE INTERVENTION2,3Deliver THE Antidote Review clues that may point to potentially life-threatening digoxin toxicity and the importance of immediate intervention.
For potentially life-threatening digoxin toxicity, think R.A.P.I.D.1-3 Recognize. Act. Promptly Infuse DIGIFab. View Efficacy Data Various cardiac dysrhythmias are associated View ECG Reference Tool References
INDICATIONS AND USAGEDIGIFab is indicated for the treatment of patients with life-threatening or potentially life-threatening digoxin toxicity or overdose, including:
IMPORTANT SAFETY INFORMATIONWarnings and PrecautionsGeneralSuicidal ingestion may result from more than one drug. Consider toxic effects of other drugs or poisons in cases where signs and symptoms of digitalis toxicity are not relieved by administration of DIGIFab. Rapid drop in serum potassium concentration may occur after treatment. Monitor frequently. Patients with poor cardiac function may deteriorate secondary to the withdrawal of the inotropic action of digoxin by DIGIFab. Monitor frequently and provide additional inotropic support if needed. Postpone re-digitalization, if possible, until the Fab fragments have been eliminated; this may require several days or a week or longer in patients with impaired renal function. Hypersensitivity ReactionsAnaphylaxis and hypersensitivity reactions are possible. Carefully monitor patients for signs and symptoms of an acute allergic reaction and if one occurs, stop the infusion and treat immediately with appropriate emergency medical care. Patients with known allergies to sheep protein or those who have previously received intact ovine antibodies or Fab are particularly at risk for an anaphylactic reaction. Do not administer DIGIFab to patients with a known history of hypersensitivity to papaya or papain unless the benefits outweigh the risks and appropriate management for anaphylactic reactions is readily available. Use of DIGIFab in Renal FailureThe elimination half-life of DIGIFab in renal failure has not been clearly defined. Monitor patients with severe renal failure who receive DIGIFab for a prolonged period for possible recurrence of toxicity. Monitoring of free (unbound) digoxin concentrations after the administration may be appropriate. Laboratory TestsDIGIFab may interfere with digitalis immunoassay measurements. Thus, standard serum digoxin concentration measurements may be clinically misleading until the Fab fragments are eliminated from the body. This may take several days or a week or more in patients with markedly impaired renal function. If possible, obtain serum digoxin samples before DIGIFab administration to establish the level of serum digoxin at the time of diagnosis. The total serum digoxin concentration may rise precipitously following administration of DIGIFab, but this will be almost entirely bound to the Fab fragment and not able to react with receptors in the body. Adverse ReactionsThe most common adverse reactions (>7%) related to DIGIFab administration are worsening congestive heart failure (13%), hypokalemia (13%) and worsening atrial fibrillation (7%). Please see full Prescribing Information. What is the most common first sign of digoxin toxicity?Gastrointestinal upset is the most common symptom of digoxin toxicity. Patients also may report visual symptoms, which classically present as a yellow-green discoloration, and cardiovascular symptoms, such as palpitations, dyspnea, and syncope.
What is the most common cause of digoxin toxicity?The most common trigger of digoxin toxicity is hypokalemia, which may occur as a result of diuretic therapy. Dosing errors are also a common cause of toxicity in the younger population. Factors that increase the risk of digoxin toxicity include: Hypothyroidism/hyperthyroidism.
What happens in digoxin toxicity?Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range. Toxicity causes anorexia, nausea, vomiting and neurological symptoms. It can also trigger fatal arrhythmias.
What are the signs and symptoms of digoxin toxicity and how would the nurse assess for these symptoms?Indications of toxicity include: Lack of appetite, nausea, vomiting, or diarrhea. Headache, confusion, anxiety, or hallucinations. Restlessness, weakness, or depression. Changes in vision such as blurred vision or seeing halos around bright objects.
|